CD8受體

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CD8a分子
Crystallographic structure of the CD8 molecule.[1]
識別
符號	CD8A
替換符號	CD8
Entrez	925
HUGO	1706
OMIM	186910
RefSeq	NM_001768
UniProt	P01732
其他資料
基因座	2 p12

CD8b分子
識別
符號	CD8B
替換符號	CD8B1
Entrez	926
HUGO	1707
OMIM	186730
RefSeq	NM_172099
UniProt	P10966
其他資料
基因座	2 p12

CD8受體（CD8-receptor）是細(xì)胞毒殺型T細(xì)胞（cytotoxic T cell）的膜上標(biāo)記（surface marker）之一。當(dāng)病菌入侵人體，有一部分必定會被廣布的抗原呈現(xiàn)細(xì)胞（此時主要指非B細(xì)胞的巨噬細(xì)胞及棘狀細(xì)胞）給吞噬，其余病菌則順利潛入正常的體細(xì)胞中。病菌無論是進(jìn)入正常體細(xì)胞或抗原呈現(xiàn)細(xì)胞，其構(gòu)成抗原的部分必會與細(xì)胞內(nèi)的MHC complex結(jié)合而表現(xiàn)在細(xì)胞外。

抗原呈現(xiàn)細(xì)胞與正常體細(xì)胞不同處，就在于抗原呈現(xiàn)細(xì)胞能“移動”至最近的淋巴結(jié)。在淋巴結(jié)中有許多CD8序列相異的、“不”具毒殺能力的T細(xì)胞，當(dāng)其中一種（可能或通常不只一種）CD8 T細(xì)胞對抗原“有反應(yīng)”，該T細(xì)胞便開始分裂、并成熟為毒殺型T細(xì)胞。毒殺型T細(xì)胞在周游人體時若“碰巧”（或是受發(fā)炎反應(yīng)物質(zhì)吸引）遇到一個受感染的正常細(xì)胞，其表面有如前所述的“抗原與MHC的結(jié)合體”，則該T細(xì)胞便會“毒殺”受感染的細(xì)胞。嚴(yán)格來說，毒殺型T細(xì)胞在“啟動”受感染的細(xì)胞的“自殺程式”（apoptosis）后便會離開。毒殺型T細(xì)胞既不“殺”（如自然殺傷細(xì)胞），也不“吞”（如巨噬細(xì)胞）。

目錄 1 參見 2 參考文獻(xiàn) 3 外部鏈接 4 參考來源

參見

• T細(xì)胞

參考文獻(xiàn)

外部鏈接

• T-cell Group - Cardiff University

蛋白質(zhì)：白血球分化抗原（參見人類白血球分化抗原列表） 1-50 CD1 Group 1 CD1 CD1A CD1D CD1E CD2 CD3 (immunology) CD3G CD3D CD3E CD4 CD5 (protein) CD6 CD7 CD8 CD8α β CD9 Neprilysin CD11 CD11a Integrin alpha M CD11c ITGAD Alanine aminopeptidase CD14 CD15 CD16 FCGR3A FCGR3B CD18 CD19 CD20 Complement receptor 2 CD22 CD23 CD24 CD25 Dipeptidyl peptidase-4 CD27 CD28 CD29 CD30 CD31 CD32 FCGR2A FCGR2B CD33 CD34 Complement receptor 1 CD36 CD37 CD38 ENTPD1 CD40 (protein) ITGA2B Glycoprotein Ib Glycoprotein IX GP1BA GP1BB GP5 CD43 CD44 PTPRC CD46 CD47 CD48 CD49 CD49a CD49b CD49c CD49d ITGA5 ITGA6 ICAM3 51-100 ITGAV CD52 CD53 ICAM-1 Decay accelerating factor CD56 B3GAT1 CD58 CD59 CD61 CD62 E L P CD63 CD64 (biology) FCGR1A FCGR1B FCGR1C Carcinoembryonic antigen CEACAM1 CEACAM8 CEACAM6 CEACAM3 CEACAM5 PSG1 (gene) CD68 CD69 CD70 CD71 CD72 NT5E CD74 CD78 CD79 CD79A CD79B CD80 CD81 CD82 (gene) CD83 CD84 CD85 LILRB3 LILRB2 LILRA3 LILRA2 LILRB1 LILRB4 CD86 Urokinase receptor CD88 FCAR CD90 LRP1 -SLC44A1 CD93 KLRD1 Fas receptor CD96 CD97 CD98 CD99 SEMA4D 101-150 IGSF2 ICAM2 ITGAE ITGB4 Endoglin VCAM-1 CD107 LAMP1 LAMP2 SEMA7A CD109 Myeloproliferative leukemia virus oncogene PVRL1 PVRL2 PVRL3 Granulocyte colony-stimulating factor receptor Colony stimulating factor 1 receptor Granulocyte macrophage colony-stimulating factor receptor CD117 Leukemia inhibitory factor receptor Interferon gamma receptor 1 CD120 TNFRSF1A TNFRSF1B CD121 Interleukin 1 receptor, type I Interleukin 1 receptor, type II IL-2 receptor IL3RA Interleukin-4 receptor Interleukin 5 receptor alpha subunit Interleukin-6 receptor Interleukin-7 receptor Interleukin-9 receptor Glycoprotein 130 CSF2RB Common gamma chain CD133 CD134 CD135 MST1R CD137 Syndecan 1 PDGFRB Thrombomodulin Tissue factor CD143 VE-cadherin CD146 Basigin PTPRJ SLAMF1 151-200 CD151 CTLA-4 CD153 CD154 CD155 CD156 ADAM8 ADAM17 ADAM10 BST1 CD158 （KIR2DL1 KIR2DL4 KIR3DL1 KIR2DS4 KIR3DL2） CD159 NKG2 KLRC2 CD160 KLRB1 P-selectin glycoprotein ligand-1 CD163 CD164 ALCAM CD167 DDR1 Discoidin domain-containing receptor 2 Hyaluronan-mediated motility receptor sialoadhesin SIGLEC5 L1 (protein) CD172 Signal-regulatory protein alpha SIRPB1 SIRPG Fucosyltransferase 3 CD177 Fas ligand CD179 VPREB1 IGLL1 CD180 Interleukin 8 receptor, alpha Interleukin 8 receptor, beta CD183 CD184 CXCR5 CXCR6 CCR1 CCR2 CCR3 (gene) CCR4 CCR5 C-C chemokine receptor type 6 C-C chemokine receptor type 7 CCR8 (gene) CCR9 CD200 201-250 Endothelial protein C receptor TEK tyrosine kinase MSR1 LY75 Mannose receptor CD207 LAMP3 DC-SIGN CDw210 Interleukin 10 receptor, alpha subunitInterleukin 10 receptor, alpha subunit Interleukin 10 receptor, beta subunitInterleukin 10 receptor, beta subunit Interleukin 12 receptor, beta 1 subunit CD213a IL13RA1 IL13RA2 IL17RA CD218 （IL18R1 IL18RAP） Insulin receptor Insulin-like growth factor 1 receptor Insulin-like growth factor 2 receptor LAG3 GGT1 IFITM1 CD226 MUC1 MFI2 LY9 PRNP Band 3 Duffy antigen system CD235 GYPA GYPB Glycophorin C Kell antigen system BCAM RHCE (gene) RHD (gene) RHAG P-glycoprotein CD244 Anaplastic lymphoma kinase CD247 - CD249 251-300 OX40L TRAIL CD254 TNFSF13 B-cell activating factor TNFSF14 TNFRSF10A TNFRSF10B TNFRSF10D RANK TNFRSF12A TNFRSF13B TNFRSF13C TNFRSF17 Low affinity nerve growth factor receptor BTLA PDCD1LG2 CD274 ICOSLG CD276 CD278 Programmed cell death 1 Mannose receptor TLR_1 TLR_2 TLR_3 TLR_4 TLR6 TLR8 TLR9 TLR10 BMPR1A BMPR1B GPR44 Leptin receptor ART4 ATP1B3 CLEC4M 301-350 CD300A CLEC10A CD302 CLEC4C Neuropilin LAIR1 LAIR2 FCRL5 Kinase insert domain receptor EMR2 NKG2D PTGFRN IGSF8 Tetherin CDCP1 CD320 F11 receptor JAM2 CDH1 (gene) CDH2 CD326 SIGLEC7 SIGLEC8 CD331 CD332 CD333 CD334 NCR1 NCR2 NCR3 ABCG2 JAG1 CD340 FZD4 FZD9 FZD10

參考來源

• 維基百科-CD8受體

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